Dr. Lina Marin DDS, MSc, PhD

Dr. Marin obtained her DDS degree from the National University of Colombia in 2007 and has pursued a professional career centred on academia and research. In 2013, she obtained her MSc in Basic Biomedical Sciences from El Bosque University (Colombia), where she worked as an instructor and researcher in cariology until 2014. She then travelled abroad to continue her graduate studies, culminating in receiving two PhD degrees in 2019, a PhD in Dentistry – Cariology conferred by the State University of Campinas, Brazil, and a PhD Biomedical Engineering Sciences – Biomaterials conferred by Western University, Canada. She pursued postdoctoral training at the College of Dentistry, University of Saskatchewan, completing her Postdoctoral Fellowship in 2022. She is currently tenure-track Assistant Professor and course coordinator for Preventive Dentistry course. 

Dr. Marin has received more than 15 awards and honors at the national and international level. In 2014 and 2020, she had the privilege of being selected to present her research at the most prestigious global research competition for oral health trainees, the IADR Hatton Award Competition, representing Colombia in 2014, and Canada in 2020. Dr. Marin has a strong publication record and a wealth of experience in varied laboratory environments integrating basic science with applied clinical research. Her research program focuses on deciphering the dynamic interaction between biofilm-forming microorganisms in the oral cavity and their host to understand the role of the biofilm and the factors and mechanisms involved in health and disease. 

Peer-reviewed publications within the last five years

1. Zambom CR, Silva GDBd, Fonseca FHd, Zolin GVS, Melo Faceto Portella Md, Marin LM, Crusca E, Krol ES, Siqueira WL, Garrido SS. Reducing Functional Domain of Histatin 5 Improves Antifungal Activity and Prevents Proteolytic Degradation. Microorganisms. 2025; 13(5):1091.

2. Marin LM, Xiao Y, Seo J, Queiroz D, Siqueira WL. Dietary carbohydrates modulate Streptococcus mutans adherence and bacterial proteome. Caries Res 2025;59(2):128-138.

3. Ahmad P, Escalante-Herrera A, Marin LM, Siqueira WL. Progression from healthy periodontium to gingivitis and periodontitis: Insights from bioinformatics-driven proteomics - A systematic review with meta-analysis. J Periodontal Res 2025;60(1):8-29. 

4. Jiang RW, Marin LM, Jaroch K, Zhou W, Siqueira WL, Pawliszyn J. Proteomic Analysis of Human Saliva via Solid-Phase Microextraction Coupled with Liquid Chromatography-Mass Spectrometry. Anal Chem 2024;96(14):5363-5367.

5. Dias LM, Cilli EM, Medeiros KS, Brasil MCOA, Marin LM, Siqueira WL, Pavarina AC. Antibiofilm Activity and Biocompatibility of Temporin-SHa: A Promising Antimicrobial Peptide for Control of Fluconazole-Resistant Candida albicans. Microorganisms. 2024;12(1):99. 

6. Ahmad P, Marin LM, Lowe C, Katselis GS, Siqueira WL. Salivary protein homology between humans and dogs: Mass spectrometry-based proteomics analysis. J Dent. 2024;142:104855.

7. Marin LM, Katselis GS, Chumala P, Sanche S, Julseth L, Penza E, Skomro R, Siqueira WL. Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis. Clin Proteom 2023;20(1):30.

8. Kolbe R, Madathil S, Marin LM, Seth R, Allison P, Quinonez C, Glogauer M, Siqueira WL, Siqueira MF. Salivary cortisol and anxiety in Canadian dentists over 1 year of COVID-19. J Dent Res 2023;102(10):1114-1121.

9. Gutierrez GM, Marin LM, Xiao Y, Escalante-Herrera A, Santos MT, Siqueira WL. Detection of periodontal disease activity based on histatin degradation in individuals with cerebral palsy. Heliyon 2022;e10134.

10. Madathil S, Siqueira WL, Marin LM, Sanaulla FB, Faraj N, Quiñonez CR, McNally M, Glogauer M, Allison P. The incidence of COVID-19 among dentists practicing in the community in Canada: A prospective cohort study over a six-month period. J Am Dent Assoc. 2022;153:450-459.e1.

11. Marin LM, Xiao Y, Cury JA, Siqueira WL. Engineered salivary peptides reduce enamel demineralization provoked by cariogenic S. mutans biofilm. Microorganisms 2022;10:742.

12. Marin LM, Xiao Y, Cury JA, Siqueira WL. Modulation of Streptococcus mutans adherence to hydroxyapatite by engineered salivary peptides. Microorganisms 2022;10:223.

13. Marin LM, Cury JA, Siqueira WL. Validation of a cariogenic biofilm model by evaluating the effect of fluoride on enamel demineralization. J Microbiol Methods 2022;192:106386.

14. Marin LM, Castiblanco GA, Usuga-Vacca MV, Cury JA, Martignon S. Chemically soluble fluoride in toothpastes marketed in Colombia. CES odontol 2021;34:3-14.

15. Castiblanco GA, Silva-Hermida BC, Opazo G M, Gonzalez-Carrera MC, Avila V, Gamboa LF, Marin LM, Usuga-Vacca M, Cortes A, Cortés-Muñoz F, Ruiz-Carrizosa JA, Martignon S. Distribution pattern of enamel fluorosis severity: What is it telling us about local fluoride exposure? CES odontol 2021;34:15-29.

16. Siqueira WL, Canales MP, Crosara KTB, Marin LM, Xiao Y. Proteome difference among the salivary proteins adsorbed onto metallic orthodontic brackets and hydroxyapatite discs. Plos One 2021;16:e0254909.

17. Caixeta DC, Oliveira SW, Cardoso-Sousa L, Cunha TM, Goulart LR, Martins MM, Marin LM, Jardim ACG, Siqueira WL, Sabino-Silva R. One-Year Update on Salivary Diagnostic of COVID-19. Front Public Health 2021;9:589564.

18. Zhu Y, Marin LM, Xiao Y, Gillies ER, Siqueira WL. pH-Sensitive Chitosan Nanoparticles for Salivary Protein Delivery. Nanomaterials. 2021;11(4):1028.

19. Pelissari CVG, Jorge JH, Marin LM, Sabino-Silva R, Siqueira WL. Statherin-derived peptides as antifungal strategy against Candida albicans. Arch Oral Biol 2021;125:105106.

20. Isho B, Abe KT, Zuo M, Jamal AJ, Rathod B, Wang JH, Li Z, Chao G, Rojas OL, Bang YM, Pu A, Christie-Holmes N, Gervais C, Ceccarelli D, Samavarchi-Tehrani P, Guvenc F, Budylowski P, Li A, Paterson A, Yue FY, Marin LM, Caldwell L, Wrana JL, Colwill K, Sicheri F, Mubareka S, Gray-Owen SD, Drews SJ, Siqueira WL, Barrios-Rodiles M, Ostrowski M, Rini JM, Durocher Y, McGeer AJ, Gommerman JL, Gingras AC. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol 2020;5(52).